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The Journal of Immunology, 1971, 106: 1185-1190.
Copyright © 1971 by The American Association of Immunologists, Inc.
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Differential Effects of Local Lymphoid Irradiation on Delayed Hypersensitivity and the Serum Antibody Response in Rats: Antigen Injection before X-Rays1

James R. Eltringham2 and Irving L. Weissman3

From the Departments of Radiology and Pathology, Stanford University School of Medicine, Stanford, California 94305

Abstract

Several time-dependent dissociations of the cellular (delayed hypersensitivity response, DHR) and humoral (hemolysin and hemagglutinin tests) responses in rats occurred following irradiation of the draining regional lymph nodes (460 R on two consecutive days or 920 R on one day) at various times after local sensitization with antigen (sheep erythrocytes (SRBC) plus Freund's complete adjuvant). The rats were also locally challenged with SRBC alone on day 9. Thus, irradiation on day 1 or 2 following initial sensitization led to augmentation of the serum hemolysin response and a slight inhibition of DHR. Irradiation on day 3 or 4 selectively inhibited the humoral response, whereas irradiation on day 6 through 8 selectively inhibited DHR. Finally, irradiation on day 9 was ineffective in inhibiting or augmenting either response.

Footnotes

1 This work was supported in part by Grant CA-10372 from the National Cancer Institute, Grant AI-09072 from the National Institute of Allergy and Infections Diseases, and Grant E-439A from the American Cancer Society.

2 J. R. Eltringham, M.D., is an Advanced Clinical Fellow, American Cancer Society.

3 I. L. Weissman, M.D., is a Senior Dernham Fellow, California Division of the American Cancer Society.






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