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Selective Inhibition of Cells in the Immune Response by Actinomycin D

From the Department of Microbiology, University of Colorado Medical Center, Denver, Colorado 80220

Abstract

A simple method is described for completely and selectively inhibiting one cell population that is required for in vitro and in vivo antibody responses to sheep erythrocyte antigens. This cell population, which is present in both 7-day immune spleen cells and in bone marrow-derived spleen cells, is completely inhibited by treatment with 0.01 µg/ml actinomycin D for 1 hr. These cells are also relatively resistant to radiation. A second cell type present in immune spleen cells is identified by resistance to this dose of actinomycin D, but is susceptible to a 10-fold higher concentration of the drug.

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				O. Sharma Induction of ovalbumin synthesis in immature chicks by actinomycin D and thioacetamide Science, October 6, 1978; 202(4363): 68 - 69. [Abstract] [PDF]