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The Journal of Immunology, 1968, 101: 446-450.
Copyright © 1968 by The American Association of Immunologists, Inc.
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Studies on the Ontogeny of the Mouse Immune System

II. Immunoglobulin-Producing Cells

Marvin L. Tyan and Leonard A. Herzenberg

From the Biological and Medical Sciences Division, U. S. Naval Radiological Defense Laboratory, San Francisco, California 94135 and Department of Genetics, Stanford School of Medicine, Palo Alto, California 94304

Abstract

It has been shown that cells which have the potential to differentiate into immunoglobulin-producing cells appear in the yolk sac, liver and caudal half of the embryo by the 9th day of gestation. Late in pregnancy these cells are found in the thymus, gut, lung, spleen, femur and peripheral blood. Certain of the data suggest that immunoglobulin-producing cell lines and those cells which mediate cell-bound immune responses arise early in gestation as separate cell populations. It has been shown that immunoglobulin synthesis per se is independent of the thymus.




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