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Stability of Human Leukocyte Granules Which Contain Histamine¹

From the Allergy-Immunology Section, Department of Medicine, Northwestern University Medical School, Chicago, Illinois.

Abstract

The stability of human leukocyte granules has been determined in several media. Distilled water alone caused release of almost all of the granular histamine. Ionic solutions of granules were stable provided that sufficient sucrose or other appropriate compounds were also present. Granules were not extruded into the medium during histamine release. In these properties leukocyte granules differ from those reported for rat peritoneal mast cells. The release of -glucuronidase was quantitatively less than the release of histamine in these experiments.

Footnotes

This work was supported in part by United States Public Health Service Research Grant A1-6139-03 from the National Institute of Allergy and Infectious Diseases and the Ernest S. Bazley Asthmatic Research Fund, Chicago Wesley Memorial Hospitals, Chicago, Illinois.

² Ernest S. Bazley Professor of Allergy and Immunology.