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Transfer of Cutaneous Hypersensitivity to Tuberculin in the Guinea Pig by G₂ from Immunized Donors¹

From the Department of Experimental Pathology, Scripps Clinic and Research Foundation, LaJolla, California

Abstract

The sera of guinea pigs that had been immunized with tubercle bacilli and had been challenged by intracardiac injection of OT 4 hr before death were effective in transferring cutaneous hypersensitivity to neutral recipient guinea pigs. The mediator was a G₂-immunoglobulin. The lesions that developed in recipients after intradermal injection of OT were considered to be the result of an antigen-antibody interaction of an Arthus or of cutaneous anaphylaxis type, rather than those of delyed hypersensitivity. The conclusion was based on the following observations: peak reactions occurred between 12 and 18 hr after skin testing; the histology was not characteristic of delayed hypersensitivity; positive transfers by serum factors could not be accomplished when delayed hypersensitivity to DNP-BGG was produced in donors; and PPD was incapable of eliciting a positive skin response in recipient guinea pigs that yielded positive test with OT.

Footnotes

This is Publication No. 255 from the Department of Experimental Pathology, Scripps Clinic and Research Foundation, LaJolla, California. This study was supported by United States Public Health Service Grant AI-07007.

² Present address: Department of Immunology, The Institute of Dermatology, St. John's Hospital for Diseases of the Skin, Homerton Grove, London, E.9, England.

³ Department of Experimental Pathology, Scripps Clinic and Research Foundation, LaJolla, California.