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Production of Rickettsial Complement-Fixing Antigens in Tissue Culture

From the United States Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, Division of Biologics Standards, Laboratory of Virology and Rickettsiology, Bethesda, Maryland

Abstract

These studies have shown that potent rickettsial complement-fixing antigens can be prepared from BS-C-1 cell cultures infected with R. prowazeki, R. mooseri, and three strains of R. tsutsugamushi. The R. prowazeki and R. mooseri antigens showed type specificity and stability. A broadly reactive R. tsutsugamushi antigen could be prepared by combining the specific antigens of the three strains employed; such a trivalent antigen has potential value in diagnostic serology.