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Regenerative Potential of Immunocompetent Cells

II. Factors Influencing Recovery of Secondary Antibody-Forming Potential from X-Irradiation¹

From the Biology Division, NCI-AEC Carcinogenesis Program, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830

Abstract

Whether or not the antibody-forming capacity of a primed animal recovers from an x-ray insult depends on the type and amount of antigen given for priming, the priming-x-irradiation interval, and the x-ray dose.

The "memory" cell compartment (PC₂) lacks the potential to recover from an x-ray insult by way of self-generation.

Recovery of the "memory" cell pool does occur, however, provided immunogen persists until uncommitted progenitor cells again become available and are stimulated to form memory cells. Thus the recovery of PC₂ is a reflection of regenerating uncommitted progenitor cells.

Footnotes

¹ This research jointly sponsored by the National Cancer Institute, and the United States Atomic Energy Commission under contract with the Union Carbide Corporation.