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Antigenic Determinants Specific for Aggregated G-Globulins¹

From the Children's Asthma Research Institute and Hospital, Denver, Colorado

Abstract

Antibodies specific for aggregated human and aggregated rabbit G-globulins have been raised in guinea pigs.

The antigenic determinants revealed by the aggregation process are species-specific, but similar, if not identical, determinants are revealed regardless of the means of nonspecific denaturation. These new determinants are located exclusively within the F_c portion of the G-globulin molecule, but are found, following aggregation, in all of a series of G myeloma proteins tested, including examples from each of the known sub-groups, G₁, G₂, G₃ and G₄. The determinants were not found however following aggregation of A- or M-immunoglobulins.

Similar antigenic determinants were found to be revealed on the G-globulin antibody molecule following combination with homologous antigen, suggesting similar structural changes in the F_c portion of the G-globulin molecule on denaturation by specific and nonspecific means.

These findings suggest a preferred structural form for aggregated (denatured) G-globulin with its own characteristic antigenic determinants and biologic properties.

Footnotes

This work was supported by Grant A1-04985 from the United States Public Health Service.

² This author wishes to acknowledge the receipt of a travel grant award by the Wellcome Foundation.