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The Detection of Antibody-Containing Cells in the Blood Stream during the IgM Cellular Antibody Response¹

From the Department of Microbiology, University of Alabama Medical Center, Birmingham, Alabama

Abstract

Evidence is presented that during the IgM response to sheep erythrocytes, significant numbers of plaque-forming cells (PFC) are circulating in the blood. The total number of PFC in the circulation did not exceed the total number in the spleen.

Comparative studies between the spleen and peripheral blood indicate that as much as 15.8% of the antibody synthesis may be taking place directly in the blood stream during a particular period. However, the response in the blood was transient: cells in the circulation did not persist for more than a few days after reaching their peak level.

Footnotes

This investigation was supported by the National Institute of Allergy and Infectious Diseases, Grant AI 798501 and the National Science Foundation Grant GB 6005.

² Present address: Dept. of Microbiology, University of Tennessee, Memphis, Tennessee.