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Antigens of Rickettsia Prowazeki

I. Activity in Complement Fixation and Mouse Protection Tests

From the Department of Health, Education, and Welfare, United States Public Health Service, National Institutes of Health, Division of Biologics Standards, Laboratory of Virology and Rickettsiology, Bethesda, Maryland

Abstract

Antigenic activities of intact rickettsiae, cell walls, protoplasm and soluble antigens of Rickettsia prowazeki were compared on the basis of weight in complement fixation and mouse protection tests. All of the materials were active in both systems. The protoplasm antigens showed the greatest specificity and heat lability in the CF test. Cell walls and soluble antigens as well as intact rickettsiae contained more heat-stable CF antigens and tended to be more active than protoplasm in the mouse protection test although differences in this activity were not statistically significant. Heating the antigens provided evidence of dissociation between heat-labile mouse-protecting antigens and heat-stable CF antigens.