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"Protein A" from Staphylococcus Aureus

IV. Production of Anaphylaxis-like Cutaneous and Systemic Reactions in Non-Immunized Guinea-Pigs¹

From the Department of Microbiology and the Department of Oral Histopathology, University of Umeå, Umeå, Sweden

Abstract

Cutaneous and systemic anaphylaxis-like reactions as well as hemorrhagic reactions were produced in nonimmunized guinea pigs by injection of a bacterial cell wall protein (protein A) from Staphylococcus aureus. These phenomena are believed to be mediated by a reaction between protein A and the Fc region of -globulin. Protein A is thus able to produce in normal guinea pigs reactions indistinguishable from immediate hypersensitivity reactions.

Footnotes

This work was supported by grants from the Medical and Odontological Faculties, University of Umeå, Umeå, Sweden, from the Swedish Cancer Society (Project 66: 60) and the Swedish Medical Research Council (Project 13x-620-02). Presented in part at Cold Spring Harbor Symposium XXXII, June 1 to 7, 1967 and at Nobel Symposium III, Stockholm June 12 to 17, 1967.

² Present address: The Wallenberg Laboratory, University of Uppsala, Uppsala, Sweden.

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