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The Journal of Immunology, 1968, 100: 507-515.
Copyright © 1968 by The American Association of Immunologists, Inc.
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The Immune Response in the Hamster

I. Definition of Two 7 S Globulin Classes: 7 S {gamma}1 and 7 S {gamma}2

John E. Coe

From the United States Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana

Abstract

A fast (7 S {gamma}1) and slow (7 S {gamma}2) 7 S {gamma}-globulin system in the hamster has been described. Specific antisera to hamster 7 S {gamma}1 and 7 S {gamma}2 were prepared, and the antigenic relationship of the papain and pepsin digests of 7 S {gamma}2 were compared to each other and to the 7 S {gamma}1-globulin. Antigenic determinants common to the 7 S {gamma}1- and 7 S {gamma}2- globulins were located in the Fab and F(ab')2 piece of 7 S {gamma}2, whereas antigenic determinants unique for the 7 S {gamma}2 whereas antigenic determinants unique for the 7 S {gamma}2 molecule were in the Fc piece of 7 S {gamma}2. The molecular size of 7 S {gamma}1-globulin was shown to be similar to that of the 7 S {gamma}2-globulin (s020, w 7.2) and the antigen-binding capacity of the 7 S {gamma}1-antibody was not detectably affected by 2-mercaptoethanol or heat treatment.






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