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Development in Hamsters of Antibodies against Surface Antigens Present in Cells Transformed by Papovavirus SV40¹

Department of Virology and Epidemiology, Baylor University College of Medicine, Houston, Texas

Abstract

Newborn hamsters inoculated with SV40 and later challenged with the homologous virus in the latent period developed antibodies which reacted specifically with antigens at the surface of hamster cells transformed by SV40. Regression of tumors induced by SV40 was consistently related with the development of this antibody. Adult hamsters vaccinated with SV40 and subsequently resisting a transplant of SV40 transformed cells developed similar antibody in their sera which could be detected as early as the 2nd week after the challenge. The evidence indicates that the S antibodies elicited by the techniques employed may be directed against SV40-specific transplantation antigens.

Footnotes

This work was supported in part by Grants CA-04600, AI-05382, and 5 T1 AI 74 from the National Institutes of Health, United States Public Health Service.

² American Cancer Society Professor of Virology.