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A New Rapid Method for Genetic Typing of Human Immunoglobulins^1,2,

Section of Hematology and Immunology, Department of Medicine, University of California School of Medicine, San Francisco, California

Abstract

A passive hemagglutination technique employing isolated -globulins and myeloma proteins of known genetic types coated onto human group O cells by CrCl₃ method has been developed. Cells thus coated have been successfully used for Gm and Inv typing of human sera. The degree of discrimination between inhibiting and noninhibiting sera is as great as with the conventional method using cells coated with incomplete anti-Rh.

Footnotes

This investigation was supported in part by Public Health Service Training Grant HE 05677 and Research Grant HE 05997 from the National Heart Institute, Public Health Service Research Grant AM 08527 from the National Institute of Arthritis and Metabolic Diseases, Contract Nonr 3656 (12) from the Office of Naval Research, and a grant from the Life Insurance Medical Research Fund.

² The nomenclature for genetic factors of human immunoglobulins and for heavy chain subtypes of IgG has been that recommended by The World Health Organization (WHO Bull., 33: 721, 1965) and The World Health Organization subcommittee respectively.

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