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The Journal of Immunology, 1968, 100: 266-273.
Copyright © 1968 by The American Association of Immunologists, Inc.
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Detection of Immune Response Against Synthetic Polymers of Amino Acids Employing the Plaque-Forming Cell System

II. Cross-Reactions of Normal Sheep Erythrocytes with Antibody Against Glutamic Acid, Lysine, Alanine and Tyrosine Terpolymers1

Patricia Walsh, Paul H. Maurer and Marianne Egan2

Department of Biochemistry, Jefferson Medical College, Philadelphia, Pennsylvania

Abstract

Plaque-forming cells which cross-react with the normal sheep erythrocyte can be induced by immunization of rabbits (but not mice or guinea pigs) with the synthetic {alpha}-L-amino acid copolymers, Glu42:Lys28:Ala30 and Glu36:Lys24:Ala35:Tyr5. A similar response cannot be induced with Glu60:Ala40, Glu60:Ala30:Tyr10, or Glu60:Lys40. The specificity of this reaction is confined to the sheep erythrocyte and was not observed with ox, turkey, goose, duck, guinea pig or rabbit erythrocytes. Soluble GLA30 polymer and sheep antirabbit globulin serum partially inhibited the formation of antibody which cross-reacted with normal sheep erythrocytes in the Jerne PFC technique.

Footnotes

This work was supported by Grants AI-03514, AI-07825, TI-AI-196 and TI-AI-334 from the National Institute of Allergy and Infectious Diseases. Paper XXV in series of Antigenicity of Polypeptides (Poly-{alpha}-Amino Acids).

2 Taken from a thesis to be submitted in partial fulfillment of the requirements for the Doctor of Philosophy degree in Biochemistry.




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M. Sela
Antigenicity: Some Molecular Aspects
Science, December 12, 1969; 166(3911): 1365 - 1374.
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