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Antigenic Properties of Mouse Lymphoma Cells¹

Departments of Biophysics and Medicine and the Laboratory of Nuclear Medicine and Radiation Biology, U.C.L.A. School of Medicine, Los Angeles, California

Abstract

The studies comprising this report show that lymphoma cells from AKR mice with spontaneously occurring disease as well as those with primary disease induced by virus have specific antigenicity. Evidence, albeit indirect, is presented to support the concept that the tumor antigens are related to specific change in antigenic properties of the cell rather than to the presence of leukemogeneic virus at the cell surface. AKR mice immunized with C3H lymphoma cells were found not to develop cytotoxicity or transplantation resistance to syngeneic cells, indicating that a state of immunologic tolerance to the lymphoma antigen is present in this high lymphoma incidence strain.

Footnotes

These studies were supported by Contract AT(04-1)GEN-12 between the Atomic Energy Commission and the University of California.