HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kodama, K. Articles by Inoue, Y. K. Search for Related Content PubMed Articles by Kodama, K. Articles by Inoue, Y. K.

Studies of Live Attenuated Japanese Encephalitis Vaccine in Swine

Biken Laboratories, Inc., Uji-shi, Kyoto, Japan and the Institute for Virus Research, Kyoto University, Kyoto, Japan

Abstract

Colostrum-deprived pigs were found to be highly susceptable to Japanese encephalitis (JE) virus even by subcutaneous inoculation. Such animals represent the most suitable host for assaying the virulence of JE virus in swine. When a small dose (10 LD₅₀) of a virulent strain was injected subcutaneously in colostrum-deprived pigs, they showed significant viremia and clinical signs, including nervous symptoms. On the other hand, an attenuated mutant (m) strain of JE virus produced no detectable viremia and no clinical symptoms even when more than 10⁷ TCD₅₀ of the virus was inoculated. The m virus was able to evoke both hemagglutination-inhibiting (HI) and neutralizing antibodies in colostrum-deprived pigs after a single subcutaneous injection. The same antibody responses were also observed after one injection of m virus in young adult pigs with HI antibody titers less than 1:10, and the antibody levels persisted for at least 80 days.

This article has been cited by other articles:

				M. R. Hilleman Toward Control of Viral Infections of Man Science, May 2, 1969; 164(3879): 506 - 514. [PDF]