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G-Antibody to Human Anti-Hemophilic Globulin (Factor VIII)¹

Department of Medicine, University of Rochester School of Medicine and Dentistry, and the Rochester General and Strong Memorial Hospitals, Rochester, New York

Abstract

Circulating factor VIII inhibitors from two patients were shown to have many of the characteristics of G-globulins, namely, resistance to heat and freezing, 7 S sedimentation coefficients, resistance to reduction and alkylation, and a decrease in sedimentation rate with pepsin hydrolysis. Loss of inhibitory activity occurred with the specific precipitation of G-globulins in one serum. No evidence of complement fixation, agar precipitin reactions or passive cutaneous anaphylaxis activity could be demonstrated.

Footnotes

¹ A preliminary report of some of this work was presented at a meeting of the Federation of American Societies for Experimental Biology, Chicago, Illinois, April 1967. This investigation was supported in part by Public Health Grants AM08849 and HE04167.

² Present address: Department of Microbiology, Northwestern University School of Medicine, Chicago, Illinois.