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Selection of Cell Populations in Induction of Tolerance: Affinity of Antibody Formed in Partially Tolerant Rabbits¹

Departments of Pathology and Medicine, New York University School of Medicine, New York, New York

Abstract

Induction of partial tolerance to a haptenic determinant, by the neonatal injection of antigen, resulted in a decrease in the affinity of the antibody formed. Thus, tolerance was more readily induced in those cells capable of synthesizing high affinity as opposed to low affinity antibody. The results are interpreted in terms of a thermodynamically driven selection of cell populations participating in immunologic reactions.

Footnotes

This investigation was supported by United States Public Health Service Grants AM-08805 and AI-3076. Computer facilities of the Section on Communication Sciences, Department of Neurosurgery, New York University School of Medicine made use of in these studies were supported by United States Public Health Service Grant FR-332.

² Supported by a training grant from the United States Public Health Service (1-F2-AI-33,253).

³ Career Scientist of the Health Research Council of the City of New York under Research Investigatorship I-464.

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