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Rhinoviruses: Basis for a Numbering System

II. Serologic Characterization of Prototype Strains¹

Children's Hospital Research Foundation and the Department of Pediatrics and Medical Microbiology, Ohio State University College of Medicine, Columbus, Ohio

Abstract

In comparative neutralization tests to enumerate serotypes among 68 rhinovirus strains, many one-way heterotypic reactions were encountered. Heterologous serum titers of 64 and above were not uncommon. This heterologous reactivity could be removed from antisera by absorption with human liver powder without altering homologous neutralizing antibody levels. It was concluded that these inhibitors were not specific for rhinoviruses and most likely are antibodies directed against host cell components.

Following the removal of nonspecific inhibitors from antisera by absorption with human liver powder, cross-neutralization test results were more readily interpreted. Fifty-five distinct serotypes and one subtype were found among the 68 rhinovirus strains.

Footnotes

This work was supported by Public Health Service Research Contract PH 43-65-562 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.

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