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Flocculation Reactions with Immune Sera Produced by Injections of Organ Emulsions

From the Laboratories of the Rockefeller Institute for Medical Research, New York

Abstract

In preceding publications the fact has been described that not only the Forssman heterogenetic antibodies but that also other hemolytic sera give characteristic flocculation with emulsions of alcoholic extract of blood corpuscles (1).

These reactions occur with many common antierythrocyte sera and are especially strong with sera obtained by injection of the substances extracted from the blood corpuscles with alcohol. Such immune sera were best produced when the extracts were mixed with a protein solution (pig serum) before injection (2).

The reactions with the common antierythrocyte sera showed a marked species-specificity but certain heterogenetic reactions were observed also.

After these facts had been established it was an obvious step to produce immune sera by injections of organ-emulsions and study their reactions. Investigations of Sachs, Klopstock and Weil (3) along the same lines will be discussed later.

It appeared in the immunization experiments that injections with organ emulsions readily produce flocculating immune sera.