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The Incidence of Two Types of Group II Human Red Blood Cells

From the Pathological Departments of Mt. Sinai Hospital and of Western Reserve University, Cleveland, Ohio

Abstract

Until recently it was believed that there were but four groups of human blood and that these could be explained as dependent upon combinations of two agglutinins and two agglutinogens. In February of last year, however, Guthrie and Huck (1) reported a third agglutinin and corresponding agglutinogen, and the finding of eight of the twenty-seven biological groups possible with three agglutinins and three agglutinogens.

They found that the traditional Group II is not a unit but composed of at least two types, the serum of each containing a single agglutinin (a) but the red cells of one type containing one agglutinogen (B) and those of the other type two agglutinogens (BC). Concerning the incidence of the types of Group II blood, they remark, "We cannot state with absolute assurance which is the commoner of these two types as it is easy to be misled from a small series."